The mRNA expression of IFN-α, IFN-β, IFN-λ1, IFN-λ2/3, IFN-γ, TNF-α, IL-1β, CCL5, IP-10, IL-18, IL-6, IL-8, IFIT2, ISG15, CXCL1 was quantified at 48h post-infection. The gene discussed is ISG15; the disease is infection.