OS results showed that expression of FDX1 was risk factor in glioma (GBMLGG) (HR = 4.17, p = 1.7e-19), LGG (HR = 2.92, p = 9.5e-6), and was protective factor in KIRC (HR = 0.48, p = 1.3e-8) and pan-kidney cohort (KIPAN) (HR = 0.59, p = 8.1e-8) (Figure 3A). This evidence concerns the gene FDX1 and central nervous system cancer.