Moreno-Eutimio et al., demonstrated that host toll-like receptors (TLRs) specifically TLR7/8 is an invader sensing receptor able to recognize ssRNA sequences of SARS –COV2, this recognition could stimulate M1 pro-inflammatory macrophages which may trigger a rapid type I IFNs(interferon) response, consequently causing innate immune hyperactivation, aberrant cytokine production and ultimately lead to acute lung injury (ALI), ARDS, multi-organ fibrosis and dysfunction (Moreno-Eutimio, et al., 2020). This evidence concerns the gene TLR7 and acute respiratory distress syndrome.