ISIS 2302 (Alicaforsen) is an RNase H-dependent 20-base-long antisense thiophosphoric oligonucleotide that inhibits human intercellular adhesion molecule-1 (ICAM-1), and it also was the first AS-ODN to be used for the treatment of IBD (Glover et al., 1997). Here, ICAM1 is linked to inflammatory bowel disease.