Under AD pathology, high concentrations of ATP or Aβ peptides promoted the activation of P2X7 in microglia, which in turn induced increased release of chemokines such as CCL3 and the recruitment of CD8+ T cells into the hippocampus and choroid plexus and exacerbated the development of central inflammation (Martin et al., 2019) (Figure 2). Here, P2RX7 is linked to Alzheimer disease.