Figure 1(e) shows the genome location of melatonergic system axis regulators on chromosomes. We then inspected the SNV frequency of melatonin modulator genes, and 974 (61.1%) samples were altered in all tested samples (Figure S2B). Several genes were frequently mutated including MAP2, PER2, PER3, CYP2C19, PER1, and ECE1. Cancers with a higher SNV burden comprised UCEC, SKCM, COAS, STAD, LUSC, LUAD, BLCA, and CESC (Figure S2C). The gene discussed is ECE1; the disease is cancer.