The latest World Health Organization (WHO) classification further divides medulloblastoma into four molecularly defined subgroups: WNT-activated, SHH-activated TP53 wildtype, SHH-activated TP53 mutated, and the non-WNT/non-SHH, which comprises two different subgroups numerically named “3” (G3) and “4” (G4) (3). This evidence concerns the gene SHH and medulloblastoma.