CGAS and malaria: As for the mouse malaria model, we firstly reported activation of cGAS-STING, and MDA5-MAVS by P. y YM infection, triggered IRF3-mediated limited production of IFN-α/β, which then induced negative regulator SOCS1 inhibit RNA-TLR7-MyD88-dependent more puissant type I IFN responses (99).