Pathogenic bacterial infection experiments showed that in the spleen and macrophages of miiuy croaker infected by V. harveyi and subjected to LPS stimulation, the relative expression trends of miR-210 and miR-3570 were significantly in contrast to those of RIPK2. Considering all of the above results, we can conclude that miR-210 and miR-3570 may participate in the immune response against pathogenic bacterial or LPS stimulation in fish by negatively regulating the NF-κB pathways via targeting RIPK2 (101). Here, RIPK2 is linked to bacterial infectious disease.