Notably, immunostimulating agents have shown promise for reversing IP, including: recombinant IL-7, programmed death 1 (PD-1)/PD-L1-specific antibodies, recombinant interferon (IFN)-γ, and recombinant GM-CSF (3, 12, 29, 62). The gene discussed is IFNG; the disease is incontinentia pigmenti.