We observed that while Ifi27l2a expression is markedly upregulated in MG, other representative Isg (Mx1, Mx2, Ifi family such as Ifi27, Ifi35, and Ifnb1, etc.)known to be upregulated by IFN response, especially type I Interferons (IFNα and β), were not measurably changed in MG. This evidence concerns the gene IFI27 and myasthenia gravis.