We observed a slightly steeper, yet not statistically significant, cognitive decline in NAC (β=-0.48) compared to Psy (β=-0.28) and SomCom (β=-0.24).<h4>Conclusions</h4>NAC feature higher proportion of <i>APOE</i> ε4 carriers, lower plasma Aβ42, worse memory performance, and a trend towards steeper cognitive decline than SomCom and Psy. The gene discussed is APOE; the disease is Mental deterioration.