There are seven coding genes significantly dysregulated in the brains of individuals with BD [data from PsychENCODE (33)] by the determined functional SNPs: NISCH, ZNF14, MTARC2, CILP2, SNX29P2, TMEM110, and KRBOX1. Importantly, this study confirmed the relevance of PACS1 in the pathogenesis of BD: two SNPs rs10896081 and rs3862386 regulate the expression of PACS1 and overexpression of this gene in mouse primary cortical neurons resulted in a reduced density of dendritic spines (43). This evidence concerns the gene KRABD1 and Behcet disease.