We then investigate the possibility that selective production of IFN-γ and/or TNF-α by CTL may be intrinsically linked to the expression of Eomes and T-bet: AML patients’ PBMCs from different timepoints post-HSCT (1M, n=13; 2M, n=13; 3M, n=15; 6M, n=19; 12M, n=12) were stimulated with CMV or WT1 peptides and then measured the expression of these transcription factors and the production of IFN-γ and/or TNF-α. The gene discussed is TNF; the disease is acute myeloid leukemia.