We used a large electronic medical record network to create propensity score-matched cohorts of patients with CML without a past history of heart or cerebrovascular diseases according to the treatment with three commonly used BCR-ABL TKIs for comparing ratios of cardiovascular outcomes (ACE, heart failure or LVEF < 50%, and VTE or pulmonary embolism) during a 5-year period. Here, ABL1 is linked to cerebrovascular disorder.