ATP6AP2 and hypertensive disorder: To further explore the method of blocking PRR and applying it to treatment, Li et al. (125) synthesized a novel antagonistic peptide, named PRO20, which is the first 20 amino acids of the (pro)renin prosegment, and interestingly, it combined with PRR and successfully inhibited Ca2 + influx and ERK1/2 activation when intraventricularly injected in rats with deoxycorticosterone acetate-salt–induced hypertension (125).