Moreover, due to the binding of SARS-CoV-2 and angiotensin converting enzyme 2 (ACE2), the available ACE2 is reduced, and the conversion of Ang II to Ang 1-7 is suppressed, causing vasoconstriction, inflammation promotion, enhanced vascular permeability, and pulmonary edema (46–48). This evidence concerns the gene ACE2 and edema.