VEGFA and diabetic retinopathy: In the Early Anti-VEGF Response and Long-term Efficacy (EARLY Analysis) of the Diabetic Retinopathy Clinical Research Network (DRCR.net) Protocol I study, Dugel et al. [189] suggested that clinicians may be able to predict long-term response after the first three anti-VEGF injections, as there was a significant correlation between the average extent of oedema in the first and second 52 weeks after treatment initiation (r = 0.673; P < 0.001), and the average extent of oedema that persisted between the first and second 52 weeks after treatment initiation.