INS and diabetes mellitus: The landmark Diabetes Control and Complications Trial (DCCT) found that 27% of people with type 1 diabetes will develop DMO within 9 years of disease onset, while the Wisconsin Epidemiologic Study of Diabetic Retinopathy (WESDR) found that the incidence of DMO in people with type 2 diabetes differed in those who needed insulin (25%) and those who did not (14%) [35–37].