Ischemic stroke triggers two main apoptotic pathways: The intrinsic pathway is initiated by the disruption of mitochondria and the release of cytochrome c, which is mediated by members of the B cell lymphoma/leukemia-2 (Bcl-2) family such as anti-apoptotic protein Bcl-2 and the pro-apoptotic protein Bcl-2-associated X protein (Bax) (Surgucheva et al., 2008; Tuo et al., 2022). This evidence concerns the gene BCL2 and ischemic stroke.