INSR and familial dilated cardiomyopathy: Xiao et al. used dataset of DCM (GSE3585) downloaded from GEO database to screen out the DEGs of DCM patients compared with control group and identified the hub genes (CTGF, IGFBP3, SMAD7, INSR, CTGF, IGFBP3) significantly related to DCM by establishing protein-protein interaction (PPI) network (Zhang et al., 2017).