Similar high area under the curve, sensitivity and specificity have been previously found for this marker in predicting amyloid-β status in pre-clinical cohorts.4,5 Also, in line with our findings, Mattsson et al.16 observed amyloid-β-dependent longitudinal increases in plasma p-tau which were correlated with longitudinal worsening of cognition and brain atrophy. This evidence concerns the gene MAPT and Brain atrophy.