The increase in DDIT3 found in DOX-treated cardiomyocytes for 24 h suggests that the increase in MitoBax may promote ER stress-related changes in DDIT3, compared to breast cancer MCF7 cells that show increased DDIT3 in response to ER stress in response to DOX as early as 3 h (Bagchi et al., 2021). The gene discussed is DDIT3; the disease is breast carcinoma.