Crucial involvements of GPCRs, such as LGR5, in both embryonic joint development (Feng et al., 2019), and postnatal joint development in juvenile mammals (Zhou et al., 2018), as well as progression of arthritis development (Li R. et al, 2022), have been identified, suggesting targeted modulation of GPCRs on cartilage as potential novel therapeutics for arthritis management. Here, LGR5 is linked to arthritic joint disease.