miR-193b-3p is significantly downregulated in patients with amyotrophic lateral sclerosis (ALS) (Chen et al., 2016) and downregulation of miR-193b-3p promotes autophagy and cell survival by targeting TSC1/mTOR signaling (Li et al., 2017). The gene discussed is TSC1; the disease is amyotrophic lateral sclerosis.