Zhong et al. studied 386 different histologic types of breast cancers for GD2 expression and demonstrated that the level of GD2 expression was influenced by tumor types (highest prevalence of GD2 in invasive lobular carcinoma), low histologic grade (G1 or G2), estrogen receptor status (highest expression of GD2 in triple-positive type), low stage and multifocality (Zhong et al., 2022). This evidence concerns the gene ESR1 and breast carcinoma.