Zhang et al. compared the cell biological characteristics between wild-type (WT) and GD3 synthase knockout (GD3S-KO) mice and found smaller gliomas and slower tumor development in GD3S-KO mice than in WT mice, which may suggest that GD3S probably enhanced the malignant properties of gliomas (Zhang et al., 2021). This evidence concerns the gene ST8SIA1 and glioma.