ETV6 and acute lymphoblastic leukemia: Most common in the context of lymphoblastic leukemias and lymphomas are thus mutations in the hematopoietic transcription factors ETV6, IKZF1 and PAX5, the tumor suppressor TP53, the DNA mismatch-repair genes MLH1, MSH2, MSH6, and PMS2 as well as ATM, NBN and the RAD51, which are indispensable for the repair of double-strand breaks (8–10, 12–16).