To verify our finding, we introduced the PTEN wildtype (WT) and various mutant form (ΔL, lipid phosphatase deficient mutant; ΔP, protein phosphatase deficient mutant; ΔLP, phosphatase dead mutant) into mouse melanoma B16F1 and rhabdomyosarcoma RMS772,39 did experimental metastasis studies in vivo. Here, PTEN is linked to melanoma.