We also examined the ATF6 expression in human melanoma by immunohistochemistry using serial tissue microarray sections compared with PTEN, Entpd5 and IGF1R (Figure 7A), and found that the ATF6 expression negatively correlated with PTEN expression (Figure S10D), while positively with Entpd5 (Figure S10E) and IGF1R (Figure S10F). This evidence concerns the gene IGF1R and melanoma.