Previous studies have found that MIF promoter activity is significantly up-regulated under hypoxia (Zis et al., 2015), and MIF is elevated in ischemic stroke in rodent models and patients (Wang et al., 2009; Zis et al., 2015; Liu et al., 2018), is associated with stroke clinical severity (Yang et al., 2017), and could predict severity and prognosis in patients with ischemic stroke (Li et al., 2017; Wang et al., 2019). The gene discussed is MIF; the disease is ischemic stroke.