Patients with PC with high PSA values had the highest HR value (vs. low PSA: HR, 19.8; 95% CI, 18.5-21.2; p < 0.001 in all PC cases and in bone metastasis cases, vs. low PSA: HR, 1.6; 95% CI, 1.37-1.86; p < 0.001). This evidence concerns the gene KLK3 and pachyonychia congenita.