However, to date, more than ten fusion genes with different counterparts of RARA have been found in roughly 1% to 2% of APL patient, contains ZBTB16-RARA(PLZF-RARA), which is the most frequent APL molecular variant (25, 26), and other translocations led to the rearrangement of RARA gene with NPM1, NUMA1, STAT5B, PRKAR1A, FIP1L1, BCOR, NABP1, TBL1XR1, GTF2I, IRF2BP2, and FNDC3B, etc, most of them were non-sensitive to ATRA and ATO (27). The gene discussed is NUMA1; the disease is acute promyelocytic leukemia.