In recent years, with the development in cytogenetics and molecular genetics, researchers have found various gene mutations and chromosomal abnormalities related to CBF-AML; the former includes mutations in FLT3, TET2, JAK2V617F, ASXL1, RAS and CBL, and the latter includes sex chromosome deletion, chromosome, 9q-, +8, +4, and chromosome 7 long arm abnormalities. This evidence concerns the gene TET2 and acute myeloid leukemia.