CRGs with low and moderate CNV, such as PDHA1, DLAT, GLS, and LIAS, were overexpressed in CRC comparison to those in normal melanoma samples, whereas CRGs with high CNV, such as PDHB, were significantly increased in melanoma samples (Figure 2D), implying that CNV may regulate CRG mRNA expression. The gene discussed is PDHA1; the disease is melanoma.