GPC3 and neoplasm: (20) enrolled 278 patients with solitary HCC, and analyzed the relationship between EOB-MR imaging features and GPC-3 positive expression, the results showed that serum alpha-fetoprotein >10 ng/ml and five EOB-MR imaging features, including tumor size >3.0cm, non-peripheral “washout”, infiltrative appearance, marked diffusion restriction, and iron sparing in solid mass were significantly associated with positive GPC-3 expression.