It has been reported that superparamagnetic iron oxide (SPIO) anti-GPC-3 molecular probes and GPC3-targeted immuno-positron emission tomography (immunoPET) can more accurately evaluate the expression of GPC-3 in HCC tissues (14–16), but SPIO and immunoPET have not yet been widely used. This evidence concerns the gene GPC3 and hepatocellular carcinoma.