A number of studies have demonstrated altered DNA methylation profiles such as the methylation levels of peroxisome proliferator-activated receptor-gamma coactivator 1a [19] and mitochondria-encoded NADH dehydrogenase in liver biopsy samples collected from NAFLD patients are important in the development of NAFLD [20]. Here, ENSG00000254051 is linked to metabolic dysfunction-associated steatotic liver disease.