In contrast, Someya et al. reported that low FoxP3 + T-cell count and low CD8 + T-cell count (cold-type tumors) in both the tumor and TME before RT were poor prognostic factors, in addition to non-squamous cell carcinoma, large pretreatment tumor volume, and three or fewer cycles of concurrent chemotherapy [26]. This evidence concerns the gene CD8A and neoplasm.