However, both adenovirus intracerebroventricular injection and recombinant irisin bilateral intrahippocampal injection are not clinically acceptable strategy for boosting brain Fndc5/irisin, thus LIPUS might be a valuable alternative approach to improve the impaired state of brain Fndc5/irisin in the CCH injure. The gene discussed is FNDC5; the disease is columnar cell hyperplasia of the breast.