By comparing them using the Wilcoxon test, we found that 12 PRGs were significantly differentially expressed, out of which 6 PRGs (GPX4, CASP4, PLCG1, CASP3, GSDMB, and AIM2) were upregulated in patients with MM (Fig. 2A). The gene discussed is CASP4; the disease is Miyoshi myopathy.