Multiple Cox regression analysis showed that baseline CD4/CD8 ratio < 0.20 (hazard ratio [HR], 2.705 [95% confidence interval (CI): 1.381–5.296]; P = 0.004}, body mass index (BMI) ≥ 24.0 kg/m2 (HR, 1.768 [95% CI: 1.225–2.552]; P = 0.002), borderline high triglyceride at baseline (HR, 3.457 [95% CI: 2.162–5.527]; P < 0.001), and 3TC + zidovudine (AZT) + EFV regimen (HR, 2.702 [95% CI: 1.593–4.581]; P < 0.001), or 3TC + TDF + lopinavir/ritonavir (LPV/r) regimen (HR, 4.349 [95% CI: 2.664–7.102]; P < 0.001) were independent risk factors for hypertriglyceridemia. Here, CD8A is linked to hypertriglyceridemia.