Multiple Cox regression analysis showed that BMI ≥ 24.0 kg/m2, baseline CD4/CD8 ratio < 0.20, borderline high TG at baseline, and the use of the 3TC + AZT + EFV regimen or 3TC + TDF + LPV/r regimen were independent risk factors for hypertriglyceridemia. Here, CD8A is linked to hypertriglyceridemia.