Moreover, serum log10IL-8 levels were positively associated with the sub-scores of RBANS delayed memory and visuospatial/constructional function in MDD patients with SSRIs, hinting that a higher concentration of serum IL-8 corresponds to improving MDD delayed memory and visuospatial/constructional by SSRIs modulating the activity of microglia and astrocytes to synthesize and release IL-8. The gene discussed is CXCL8; the disease is major depressive disorder.