Double-hit or Triple-hit lymphoma (DHL/THL) is an uncommon subset of B cell non-Hodgkin lymphoma with recurrent translocations involving MYC/8q24 and BCL2/18q21 and/or BCL6/3q27, according to the 2016 updated WHO classification of lymphoid neoplasias [1]. The gene discussed is MYC; the disease is lymphoma.