The 5th edition of the World Health Organization Classification of Lymphoid Neoplasms was published in 2022, and only the high-grade B cell lymphoma involving MYC and BCL2 rearrangements was retained in this entity (DHL), while lymphoid neoplasms with dual MYC and BCL6 rearrangements are now classified either as a subtype of DLBCL, NOS or HGBL, NOS according to their cytomorphological features [20]. The gene discussed is MYC; the disease is diffuse large B-cell lymphoma.