THBD and infection: Second, the high mortality of C. canimorsus-associated MALS can be ascribed more to the occurrence of DIC than to the infection by itself; consequently, measures aiming to restore the anticoagulant capabilities, including the administration of FFP and AT III, should be adopted; the administration of PC zymogen concentrates could be considered, but the reduced or absent levels of thrombomodulin might prevent its activation.