Further result should be conducted in the future to enhance the understanding of drugs with potential therapeutic effects to treat atherosclerosis via IKKβ, such as additional validation experiments, comparative efficacy experiments among different drugs, and multicellular targeting experiments and clinical trials, etc. Understanding the pathogenesis of diseases associated with impaired IKKβ activity may provide insight into prevention and treatment of these human diseases. The gene discussed is IKBKB; the disease is atherosclerosis.