TIMD4 and coronary artery disorder: We note that we did not observe strong genetic evidence for an association between rare or common genetic variation at TIMD4 for coronary artery disease (cis-pQTL: protein decreasing T-allele, OR [95% CI] = 1.04 [1.02-1.07], p-value=0.002; gene burden: OR [95% CI] = 1.3 [0.90-1.88], p-value=0.16), which may weaken the expectation that pharmacological modulation of TIMD4 could address the residual burden of CAD despite lipid-lowering treatment.