DKKL1 and multiple sclerosis: For example, we identify DKKL1 as a candidate causal gene for multiple sclerosis (MS), potentially through a role in B-cell hyperactivity, which may provide late genetic evidence for depletion of B-cells being one of the most effective treatments for MS, a therapeutic strategy that originally emerged from clinical and neuropathological studies (44, 45) (see Supplementary Note 1).