However, the percentage of macrophages with engulfed tumor cells, as represented by GFP, CD11b, and F4/80 triple-positive cells (GFP+CD11b+F4/80+), in the total CD11b+F4/80+ macrophages was significantly lower in the RRAGA knockdown tumor (Fig. 1h, i), supporting that the knockdown of RAGA inhibits tumor macrophage phagocytosis in vivo. The gene discussed is ITGAM; the disease is neoplasm.