However, the percentage of macrophages with engulfed tumor cells, as represented by GFP, CD11b, and F4/80 triple-positive cells (GFP+CD11b+F4/80+), in the total CD11b+F4/80+ macrophages was significantly lower in the RRAGA knockdown tumor (Fig. 1h, i), supporting that the knockdown of RAGA inhibits tumor macrophage phagocytosis in vivo. This evidence concerns the gene RRAGA and neoplasm.