Since long-lasting multifunctional-tissue-resident (TRM) Ag-specific T cells at respiratory mucosal surfaces induced following vaccination are critical for effective host defense against pulmonary TB40,55–57, we next evaluated the longevity, functionality and phenotypic characteristics of Ag-specific T cells induced following Tri:ChAd:TB vaccination and compared that to Ag-specific T cells induced by its monovalent counterpart. This evidence concerns the gene RENBP and tuberculosis.