This process is associated with differential M.tb antigen (Ag) expression with some Ags such as Ag85 complex proteins (AgA/B/C) predominantly produced during the acute stage of infection, some including ESX secretion system proteins (TB10.4, ESAT6 etc.)produced throughout the course of infection, and some expressed during either the latency/dormancy or resusciation6,13,17,21,22. Here, AGA is linked to infection.