Depletion of endogenous PLEKHA7 in two GC cell lines (AGS and MGC803) with high endogenous PLEKHA7 expression using two independent shRNAs or sgRNAs (Fig. 2E and Fig. S2A, B), resulting in the invasion/migration ability of these two cell lines was significantly increased compared with that in the control group after depleting PLEKHA7 (Fig. 2F, G and Fig. S2C). Here, PLEKHA7 is linked to gastric cancer.