SOAT1 and asthma: In a second example (Fig. 3d and Supplementary Table 3), we identified a group of ten respiratory (for example, asthma) and cutaneous (for example, eczema) immune-related diseases that share three gene modules: a highly pleiotropic module related to regulation of transcription and proteasome, and two more specific modules related to pattern recognition receptor signaling and cytokine production with Janus kinase/signal transducer and activator of transcription (JAK–STAT) involvement.