In this study we tested the following hypotheses: (1) RNF43 and LRP1B are of tumor biological significance in GC; (2) RNF43 and LRP1B show intratumoral heterogeneity; (3) RNF43-expression and LRP1B-expression correlate with clinicopathological patient characteristics and show differences with regard to histological type of Lauren. Here, RNF43 is linked to gastric cancer.