CD8A and central nervous system cancer: Our observation that 2-HG reduction was associated with the induction of genes associated with antitumor immunity and a modest increase in tumor infiltration with CD8+ T cells is consistent with an immunosuppressive effect of 2-HG on the glioma microenvironment, as suggested by previous studies31,32, and raises the intriguing possibility that inhibition of the mutant enzyme might synergize with other strategies to promote antitumor immunity against mIDH gliomas.