Examination of formalin-fixed, paraffin-embedded (FFPE) tumor tissue from the resection showed an inverse correlation between tumor 2-HG and tumor-infiltrating CD3+ and CD8+ T cells (Fig. 2g), and again showed an association between 2-HG suppression and upregulation of antigen presentation and the IFN pathways (Extended Data Fig. 6). This evidence concerns the gene CD8A and neoplasm.