Matched-pair analysis from surgery 1 (archival tumor tissue from previous surgery) and surgery 2 (on-treatment surgery) suggested that more complete tumor 2-HG suppression was required to promote tumor infiltration with CD3+/CD8+ T cells (Extended Data Fig. 7a,b) and inhibit tumor cell proliferation (Extended Data Fig. 7c,d). This evidence concerns the gene CD8A and neoplasm.