Lou et al. observed that an EMT signature was associated with increased expression of various immune inhibitory ligands and receptors (e.g., PD-L1, PD-1, CTLA-4, T-cell immunoglobulin mucin-3 (TIM-3), LAG-3 and B7 Homolog 3 (B7-H3)) in lung adenocarcinomas [96]. This evidence concerns the gene CD274 and lung adenocarcinoma.