Besides EMT-TFs, small non-coding RNAs such as exosomal miR-106b derived from colorectal cancers with mesenchymal features induced M2 macrophage via IL-6 secretion [172], and long non-coding RNAs such as Lon-PYCR1 promotes EMT in oral squamous cell carcinoma and stimulates M2 macrophage polarization through IL-6 and VEGF-A [173]. The gene discussed is IL6; the disease is oral cavity squamous cell carcinoma.