CD8A and melanoma: Using gain- and loss-of-function approaches in syngeneic mouse melanoma xenograft models, Plaschka and colleagues demonstrated that ectopic ZEB1 expression in melanoma cells is associated with reduced CD8+ T-cell infiltration, because it directly inhibited the secretion of T-cell-attractive chemokines, including chemokine (C-X-C motif) ligand 10 (CXCL10) [164].