Interestingly, the combination of galunisertib with an anti-PD-1 or anti-PD-L1 antibody eliminated established metastases [230], as well as promoted tumor regression of a mouse xenograft models established with the Lewis lung cancer (LCC) cell line, primary esophageal squamous-cell cell line MEC2 and colorectal cancer cell line CT26 [231, 232]. The gene discussed is CD274; the disease is lung carcinoma.