CDH1 and neoplasm: Tumors with different degrees of EMT undergo a series of physical changes including tight junction dissolution, cell polarity alterations (e.g., Par, Crumbs, and Scribble complexes), cytoskeletal rearrangements, the loss of epithelial cell markers (e.g., E-cadherin, integrins, EpCAM, Claudin), and the emergence of mesenchymal cell markers (e.g., N-cadherin, vimentin, fibronectin) [178], which not only increase tumor motility and migration [31, 157, 195], but also affect the contact with immune cells.