PRMT4 has also been shown to suppress glutamine metabolism in pancreatic ductal adenocarcinoma by methylating malate dehydrogenase 1 (MDH1), or inhibits HCC glycolysis by methylating glyceraldehyde-3-phosphate dehydrogenase, both leading to reduced growth and proliferation of cancer cells34,35. Here, MDH1 is linked to pancreatic ductal adenocarcinoma.