PRMT4 has also been shown to suppress glutamine metabolism in pancreatic ductal adenocarcinoma by methylating malate dehydrogenase 1 (MDH1), or inhibits HCC glycolysis by methylating glyceraldehyde-3-phosphate dehydrogenase, both leading to reduced growth and proliferation of cancer cells34,35. This evidence concerns the gene CARM1 and pancreatic ductal adenocarcinoma.